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UK experts say they may have found a way to check for Alzheimer's years before symptoms appear. A lumbar puncture test combined with a brain scan can identify patients with early tell-tale signs of dementia, they believe. Ultimately, doctors could use this to select patients to try out drugs that may slow or halt the disease. Currently there is no single test or cure for dementia, a condition that affects over 800,000 people in the UK. Experts are working hard to find treatments that prevent the disease or at least slow its progression. Unmet need Although there are many candidate drugs and vaccines in the pipeline, it is hard for doctors to test how well these work because dementia is usually diagnosed only once the disease is more advanced. Dr Jonathan Schott and colleagues at the Institute of Neurology, University College of London, believe they can now detect the most common form of dementia - Alzheimer's disease - at its earliest stage, many years before symptoms appear. Their approach checks for two things - shrinkage of the brain and lower than normal levels of a protein, called amyloid, in the cerebrospinal fluid (CSF) that bathes the brain and spinal cord. Experts already know that in Alzheimer's there is loss of brain volume and an unusual build up of amyloid in the brain, meaning less amyloid in the CSF. Dr Schott's team reasoned that looking for these changes might offer a way of detecting the condition long before than is currently possible. To confirm this, they recruited 105 healthy volunteers to undergo a series of checks. The volunteers had lumbar puncture tests to check their CSF for levels of amyloid and MRI brain scans to calculate brain shrinkage. The results, published in Annals of Neurology, revealed that the brains of those normal individuals with low CSF levels of amyloid (38% of the group), shrank twice as quickly as the other group. They were also five times more likely to possess the APOE4 risk gene and had higher levels of another culprit Alzheimer's protein, tau. Continue reading the main story “Start Quote Detecting dementia early is really important. It can open doors to new treatment targets...” End Quote Dr Anne Corbett of the Alzheimer's Society Although it is too soon to know if any of the volunteers will go on to develop Alzheimer's, the researchers believe their suspicions will be confirmed in the future. Crucially, it would allow doctors to test which drugs might be beneficial in delaying or preventing dementia. Preventive opportunity And for those who might be put off such screening by the need for a lumbar puncture, which involves drawing off fluid from around the spinal cord with a needle, experts are looking at whether a different type of brain scan might instead be used to detect amyloid...

Early Alzheimer's test possible

Small amounts of processed meat increase the risk of developing heart disease, while red meat does not, research suggests. A Harvard University team which looked at studies involving over one million people found just 50g of processed meat a day also raised the risk of diabetes. But there was no such risk from eating even twice as much unprocessed meat, such as beef, lamb or pork. This was despite the fact the two forms of meat have a similar fat content. Writing in the journal Circulation, the researchers speculated that given the similar quantities of cholesterol and saturated fats, the difference may be explained by the salt and preservatives added to processed meats. This is defined as any meat preserved by smoking, curing or salting and includes bacon, sausages, salami and other luncheon meats. Salt can increase blood pressure in some people, a key risk factor for heart disease. In animal experiments, nitrate preservatives can promote atherosclerosis and reduce glucose tolerance, which can in turn lead to heart problems and diabetes. Similar lifestyle The team from Harvard School of Public Health looked at 20 studies involving more than one million participants from 10 countries. On average, each 50g serving of processed meat per day - the equivalent of a sausage or a couple of rashers of bacon - was associated with a 42% higher chance of developing coronary heart disease and a 19% higher risk of diabetes. "Although cause-and-effect cannot be proven by these types of long-term observational studies, all of these studies adjusted for other risk factors," said Renata Micha, lead author. "Also, the lifestyle factors associated with eating unprocessed meats and processed meats were similar, but only processed meats were linked to higher risk." Victoria Taylor, senior heart health dietician at the British Heart Foundation, said: "If you like red meat, this can still be included as part of a balanced heart-healthy diet. "Go for lean cuts and aim to cook from scratch using healthier cooking methods like grilling or baking. If you need to add flavour, then try using fresh and dried herbs, spices and chillies instead of salt." A spokesman for BPEX, which represents pork producers, insisted processed meats could form part of a balanced diet. He suggested further research was needed before any dietary recommendations could be made. "Various studies indicate that high consumption of processed meat can be indicative of an overall poorly balanced diet: therefore it could be other aspects of the diet that are contributing to the increase in risk," he added.

Sausage a day 'raises heart risk'

Eating nuts may help lower cholesterol levels, US research suggests. The review of 25 studies, involving nearly 600 people, showed eating on average 67g of nuts - a small bag - a day reduced cholesterol levels by 7.4%. The US Loma Linda University team believes nuts may help prevent the absorption of cholesterol. UK experts said the research showed nuts were an important part of a healthy diet, but warned against eating nuts covered in sugar or salt. Previous work has indicated eating nuts regularly is beneficial, but the Archives of Internal Medicine study set out to put an accurate figure on the effect.

Eating nuts 'lowers cholesterol'